Vyjayanthi Krishnan
Ph.D.
2000
Peptide synthesis, molecular and cell biology, enzyme assays
First Lipophilically Modified Peptide Analogs of Gi(alpha) N-terminus that Affect Muscarinic Receptor Ligand Binding
Email: vyjoo@hotmail.com
2006 -
Scientist, Wellstat Biologics
Gaithersburg, MD,
Anticancer oncolytic virus therapy development
2000 - 2006
NIH: Postdoctoral Fellow
with Steven L. Zeichner, M.D., Ph.D.
HIV and DNA arrays.
Papers
Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL.
Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway.
J. Virol. 2005, 79, 17, 11366-11381.
Abstract
Vyjayanthi Krishnan, Steven L. Zeichner
Alterations in the expression of DEAD-box
and other RNA binding proteins during HIV-1 replication
Retrovirology 2004, 1, 1, 42.
Abstract
Vyjayanthi Krishnan, Steven L. Zeichner
Host Cell Gene Expression during Human Immunodeficiency Virus
Type 1 Latency and Reactivation and Effects of Targeting Genes
That Are Differentially Expressed in Viral Latency
Journal of Virology 2004, 78, 17, 9458–9473.
Abstract
Syed Shaheduzzaman*, Vyjayanthi Krishnan*, Ana Petrovic, Michael Bittner, Paul Meitzer,
Jeffrey Trent, Sundrararajan Venkatesan, Steven Zeichner
Effects of HIV-1 Nef on Cellular Gene Expression Profiles
J. Biomed Sci 2002, 9, 1, 82-96.
* Indicates that V.K. and S.S. contributed equally to work.
Abstract
Vyjayanthi Krishnan, Wellington N. Pham, Wiliam S. Messer, Jr., Steven M. Peseckis
First fatty acylated dipeptides to affect muscarinic receptor ligand binding.
Bioog. Med. Chem. Lett. 1999, 9, 23, 3363-3368.
News
NIH article on HIV latency in cells paper and work done by Vyjayanthi Krishnan in Steven L. Zeichner's laboratory posted August 16, 2004
BioCentury (The Bernstein Report on BioBusiness), Vol 12, Number 37, p A9 of 18 published on August 23, 2004 called "HIV hide and seek" was based on an interview with Dr Krishnan. In the article they quotes her as saying that "There is no real phenotype difference between a cell that is not infected and a cell that is latently infected." - Vyjanthi Krishnan of NCI (National Cancer Institute).
Wellington Pham
Ph.D.
2000
Organic synthesis, method development, enzyme assays
Design, Synthesis, and Biological Evaluation of Dual Fatty Acylated Peptide Mimetics of Gi(alpha) N-Termini
Email: wellington.pham@vanderbilt.edu
2006 - Present
Assistant Professor of Radiology and Radiological Sciences
Vanderbilt University, University Medical Center
Institute of Imaging Science
2004-2006
Instructor in Radiology at Harvard Medical School
Assistant Chemist at Massachusetts General Hospital
Department of Radiology, MGH
Athinoula A. Martinos Center for Biomedical Imaging
Multiple imaging project areas
2001-2004
Postdoctoral Fellow, Harvard University/Massachusetts General Hospital
with Ching H. Tung, Ph.D.
Molecular imaging compounds, multiple project areas
2000-2001
UCLA: Postdoctoral Fellow
with Tatsushi Toyokuni, Ph.D.
Biological imaging agents
Papers
Medarova Z, Pham W, Kim Y, Dai G, Moore A.
In Vivo Imaging of Tumor Response to Therapy Using a Dual-Modality Imaging Strategy.
Int. J. Cancer 2006, 118, 2796-2802.
Paper
Pham W, Pantazopoulos P, Moore A.
Imaging Farnesyl Protein Transferase Using a Topologically Activated Probe.
J. Am. Chem. Soc. 2006, 128, 36, 11736-11737.
Thumbnail Abstract
Abstract
Pham W, Medarova Z, Moore A.
Synthesis and application of a water-soluble near-infrared dye for cancer detection using optical imaging.
Bioconjugate Chem. 2005, 16, 3, 735-740.
Abstract 1 Abstract 2
(same abstract, different sources)
Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A.
Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging.
Neuroimage 2005, 28, 287-292.
Abstract
John W. Chen, Wellington Pham, Ralph Weissleder, and Alexei Bogdanov, Jr.
Human Myeloperoxidase: A Potential Target for Molecular MR Imaging in Atherosclerosis
Magnetic Resonance in Medicine 2004, 52, 1021–1028.
Abstract
Wellington Pham, Yongdoo Choi, Ralph Weissleder, and Ching-Hsuan Tung
Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing
Bioconjugate Chem. 2004, 15, 1403-1407.(Special feature on imaging chemistry)
Abstract
Wellington
Pham, Moritz F. Kircher, Ralph Weissleder, and Ching-Hsuan Tung
Enhancing Membrane Permeability by Fatty Acylation of Oligoarginine
Peptides
ChemBioChem 2004, 5, 1148-1151.
Wellington Pham, Wen-Fu Lai, Ralph Weissleder, and Ching-Hsuan Tung
High Efficiency Synthesis of a Bioconjugatable Near-Infrared Fluorochrome
Bioconjugate Chem. 2003, 14, 1048-1051.
Abstract
Wellington Pham, Ralph Weissleder, and Ching-Hsuan Tung
A practical approach for the preparation of monofunctional azulenyl squaraine dye
Tetrahedron Letters 2003, 44, 3975-3978.
Wellington Pham, Ralph Weissleder, and Ching-Hsuan Tung
An Azulene Dimer as a Near-Infrared Quencher
Angew. Chem. Int. Ed. 2002, 41, 9, 3659-3662.
Wellington Pham, Ralph Weissleder, and Ching-Hsuan Tung
Intermolecular [8+2] cycloaddition reactions of 2H-3-methoxycarbonylcyclohepta[b]furan-2-one
with vinyl ethers: an approach to bicyclo[5.3.0]azulene derivatives
Tetrahedron Letters 2001, 43, 19-20.
Vyjayanthi Krishnan, Wellington N. Pham, Wiliam S. Messer, Jr., Steven M. Peseckis
First fatty acylated dipeptides to affect muscarinic receptor ligand binding.
Bioog. Med. Chem. Lett. 1999, 9, 23, 3363-3368.
News
Synthesis Community at Vanderbilt includes Wellington Pham.
ISMRM 14th Scientific Meeting & Exhibition, 6-12 May, 2006
Poster Award Winner, 1st Place Program No. 1743
Tumor-Antigen Targeted Imaging of Pancreatic Adenocarcinoma
Zdravka Medarova1,, Wellington Pham1,, Young Kim1,, Guangping Dai1,, Anna Moore1,
Massachusetts General Hospital, Charlestown, Massachusetts, USA
Online Article: Peptide-based molecular beacons for cancer detection
Wellington Pham and Anna Moore
Athinoula A. Martinos Ctr. for Biomedical Imaging, Harvard Medical School
(published online Nov. 22, 2005)
Powerpoint Presentation connected to Pham's MGH work.
Thanked for assistance with chemistry.
News release: Newly equipped molecular probes may improve early detection of cancer, other diseases. BOSTON - August 19, 2002
Honor: Massachusetts General Hospital, Harvard University
Center for Molecular Imaging Research
2000/2001 NIH Fellow (01/01-01/03)
Rahim Lila
Ph.D.
2002
Informatics (databases, programming), molecular biology, enzyme assays
A New Bioinformatic Resource: A Heterotrimeric G-Protein Database (hGPDB)
Email: rlila@amgen.com
2006 - Present
Amgen, Inc.
Research Informatics
2002 - 2006
Scitegic, Inc.
Application Support / Developer
Marc Christensen
Marc C. Christensen
Ph.D.
2006
Computational modeling and molecular dynamic analysis of G protein-coupled receptors in lipid bilayer environment
Email: mchrist551@hotmail.com
2006 - Present
Pharmacy
Rick Dudley
Richard W. Dudley
Ph.D.
2006
Synthesis and examination for cellular entry and localization of lipophilically modified fluroescently tagged small molecules
Email: rickyiii60@hotmail.com
2006 - Present
Pharmacy; Research Associate, The University of Toledo
Botao (Zhoa) Kocz
1995-1997
Synthesis of Azapeptides for N-myristyltransferase inhibition
Email: Botao.Kocz@usa.xerox.com
1997 - Present
Xerox Corporation Information system management / database specialist
